Endocrine Abstracts

Introduction: There were some studies on the relation between subclinical hypothyroidism and arteriosclerosis, but few studies between thyroid function and diabetic microangiopathy. This study was aimed at investigating the influence of subclinical hypothyroidism on diabetic complications in Japanese population.Description of methods/design: We retrospectively surveyed a total of 106 type 2 diabetic patients with regard to thyroid function and microvascu...

Introduction: Recent reports showed that 2–9.4% of diabetic patients have Cushing’s syndrome (CS) including its mild form, subclinical CS (subCS), but there is no report about screening of acromegaly in diabetic patients. Either 1-mg or 0.5-mg dexamethasone suppression test (DST) is used as the screening test of adrenal CS or Cushing’s disease (CD). The aim of the present study was to screen CS including CD and acromegaly in Japanese diabetic patients.<p cla...

Introduction: Recent studies have elucidated that C-type natriuretic peptide (CNP), a member of natriuretic peptide family, is a potent stimulator of endochondral bone growth; CNP and its membranous guanylyl cyclase receptor, GC-B are expressed in growth plate, and mice with targeted overexpression of CNP in growth plate exhibit prominent skeletal overgrowth, whereas CNP or GC-B knockout mice develop severely short stature phenotype owing to their impaired endochondral bone gr...